Enalapril maleate and a lysine analogue (MK-521): disposition in man.

Simultaneous Determination of Hydrochlorothiazide and Enalapril Maleate in Pharmaceutical Formulations Using Fourier Transform Infrared Spectrometry

A new Fourier Transform-Infra Red (FT-IR) spectrometric method was developed for assaying hydrochlorothiazide (HCT) and enalapril maleate (ENM) in binary solid pharmaceutical formulations. Multivariate Partial Least Squares (PLS) method was used for calibration of derivative spectral data. Acetonitrile was used as solvent due to its spectral tran...

Formulation and Evaluation of Mucoadhesive Buccal Films of Enalapril Maleate

Enalapril maleate is used in the treatment of hypertension and angina pectoris. It shows low bioavailability due to high hepatic first pass metabolism. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study ten formulations of mucoadhesiv...

Polymorphic hydroxylation of perhexiline maleate in man.

Long term perhexiline maleate therapy causes peripheral neuropathy and hepatic damage in certain subjects. An association between these adverse reactions and a genetically determined relative inability to hydroxylate debrisoquine has been described. This association could indicate either that the effects of perhexiline impair debrisoquine oxidation thus producing a phenocopy, or that perhexilin...

Design and Characterization of Oral Dispersible Tablets of Enalapril Maleate Using a Co-Processed Excipient

Article history: Received on: 20/10/2012 Revised on: 06/11/2012 Accepted on: 15/11/2012 Available online: 28/11/2012 In the present work, oral dispersible tablets of Enalapril maleate were prepared using three different superdisintegrants and a co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate in the ratio 1:1. Oral dispersible tablets of Enalapril maleate we...

Stability of Extemporaneously Prepared Enalapril Maleate Suspensions in Glass Bottles and Plastic Syringes.